Aggravation of non-steroidal anti-inflammatory drug-induced hepatitis and acute renal failure by slimming drug containing anthraquinones.

The renal toxicities of non-steroid anti-inflammatory drugs (NSAIDs) have been well reported [1] and the mechanism of injury is thought to be mediated by haemodynamic perturbation which results in functional renal ischaemia. The typical histological abnormality is acute tubular necrosis, which is usually reversible. Anthraquinone and its derivatives are frequently found in slimming agents and have been valued for their cathartic and presumed detoxifying action. Diarrhoea, vomiting and abdominal discomfort are common side-effects, and in severe cases, may result in dehydration. Renal and liver complications resulting from the combined use of NSAID and anthraquinonecontaining slimming agent have not reported. The current report highlighted the potential risk of NSAIDs when given in a patient on weight reduction treatment. The popularity of proprietary slimming drugs obligates due precaution be taken when NSAID is prescribed.